Through 12 weeks of the 2011 NFL season, for QBs with at least 2000 passing attempts that is Aaron Rodgers of the Green Bay Packers who has 124 career TD passes and 37 career INTs for a 3.35 to 1 TD/INT ratio.
Tom Brady of the New England Patriots is second with 291 career TD passes and 113 career INTs for a 2.58 to 1 TD/INT ratio.
132 touchdowns to 38 interceptions so far in his career
Through the 2007 season, Favre has thrown 442 TDs and 288 INTs for a touchdown to interception ratio of 1.53 (to 1).
4.2 touchdowns for every 2.5 interceptions.
Spergon Wynn threw 1 Touchdown and 7 Interceptions in his career. I'm pretty sure 1/7 ratio is the worst ever by. And the worst part is he was chosen before Tom Brady by the Cleveland Browns.
As of October 2023, Aaron Rodgers holds several notable NFL records, including the highest career passer rating in league history at over 104.5 and the most touchdown passes per game with an average of 0.87. He also has the record for the most consecutive seasons with a passer rating of 100 or higher, demonstrating his sustained excellence over his career. Additionally, Rodgers is known for his impressive touchdown-to-interception ratio, one of the best in NFL history.
2010 Tom Brady had a 9 to 1 Td/Int ratio. 36 touchdowns to 4 interceptions.
Through the 2011 season, Tebow threw or passed for 29 touchdowns while only have nine interceptions so his ratio is 9/29.
Although he played division III, his record is so outstanding I think it is a good answer to this question. The best I can find is Bill Borchert, the QB at Mt. Union from 1994 thru 1997. His career TD/Int ratio was 141/17. His best season was 1997, at 47/1.
As of the start of the 2008 season, for a single season that would be Tom Brady in 2007 with 50 TD passes and 8 INTs for a TD to INT ratio of 6.25. Through the 2010 season, that honor belongs to Aaron Rodgers of the Packers with a 2.71 to 1 TD to INT ratio (87 career TD passes and 32 career INTs). Tom Brady of the Patriots is second at 2.53 to 1 (261 career TD passes and 103 career INTs). Everyone at the top of this list is a QB that is currently playing or played in the last 10 years. It is rare to find a QB that played his entire career in the 20th century that has a 2 to 1 ratio. Steve Young is an exception at a 2.17 to 1 ratio (232 TDs/107 INTs). Randomly selecting some all time greats, Sammy Baugh is .92 to 1 (187 TDs/203 INTs), John Unitas is 1.15 to 1 (290 TDs/253 INTs), Terry Bradshaw is 1.01 to 1 (212 TDs/210 INTs), Joe Montana is 1.96 to 1 (273 TDs/139 INTs), Dan Marino is 1.67 to 1 (420 TDs/252 INTs), and John Elway is 1.33 to 1 (300 TDs/226 INTs). For more information, please refer to the related links.
Touchdowns per interception ratio, three superballs wins in first six seasons
Muggsy Bogues is the all time assist to turnover leader with a career mark of 4.69.
See the link below