Through the 2008 season, that is Dan Marino with 420. Brett Favre holds the record with 463.
Brett Favre holds the record with 464 touchdown passes.
tom brady 2009
Tom Brady holds the record with 50 touchdown passes
Jerry Rice currently holds the single season record with 22 touchdowns in the 1987 season with the San Francisco 49ers
Most touchdown passes in a single season-50, Tom Brady, New England Patriots, 2007
Barry Sanders with 39.