Steve sleton holds the record with 654 rushing yards
Emmitt Smith holds the record for most rushing yards in a career with 18,355 yards. Eric Dickerson holds the record for most rushing yards in a season with 2,105 yards. Adrian Peterson holds the record for most rushing yards in a single game with 296 yards.
Denard Robinson from the University of Michigan holds the record for most rushing yards by a quarterback in a season with 1,538 yards. Robinson also holds the record for most career rushing yards by a QB in NCAA history with 4,495 yards.
As of the 2007 season: In the NFL, the record for career rushing yards is held by Emmitt Smith with 18,355. In college football, the Division 1-A record for career rushing yards is held by Ron Dayne with 6,397.
Pat White holds the QB rushing record.
As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
Michael Vick has the most rushing yards by a quarterback with 5,139 yards.
Emmitt Smith,with 18,355 rushing yards, currently holds the record for the highest rushing yards in the game.
Timmy Smith (204 Rushing yards).
Ricky Williams holds the 1-A rushing record for the ncaa at 6.138 yards from the University of Texas. Ron Dayne from the University of Wisconsin holds the D1A career rushing record with 6,397 yards between 1996-1999.
Barry Sanders retired with the Lions' rushing record in 1999.
Emmitt Smith 18,355 rushing yards
Emmit Smith..18,355 yards..........loved the guy
Eric Dickerson with 2,105 yards.
Eric Dickerson currently holds the record for a single season by rushing 2,105 yards. When he made this record, he was playing for the Los Angeles Rams. In 2012 Adrian Peterson got just 8 yards of this record.
In a career, Randall Cunningham holds the record for rushing yards by a Quarterback with 4928. Michael Vick does hold the single season record with 1039 yards.
As of December, 2008 the answer to this question is Nate Kmic from Mount Union College. Kmic finished one of the best seasons ever for a college running back and now holds college football's record for career rushing yards with 8,074 yards. This season Kmic ran for a record 2,790 yards with 43 rushing and 44 total touchdowns as he led the Purple Raiders to their 10th NCAA Division III National Championship with a 31-26 win over UW-Whitewater.
Eric Dickerson, who played for the Rams, Colts, Raiders, and Falcons between 1983-1993, holds the NFL record for rushing yards in a season when he gained 2,105 yards for the Los Angeles Rams in 1984.