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That would be the great (seriously) Reggie Jackson who struck out 2597 times, more than 200 more times than second place, Sammy Sosa, who struck out 2306. Jackson is in the Hall of Fame, Sosa would have been if not for steroids but will most likely be voted in by the veterans committee.

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15y ago
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14y ago

Reggie Jackson holds the record for the most strikeouts in a single career in Major League Baseball, in his career he struck out 2,597 times.

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Q: Who has struck out the most as a Major League Baseball hitter?
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