Through 12 weeks of the 2011 NFL season, for QBs with at least 2000 passing attempts that is Aaron Rodgers of the Green Bay Packers who has 124 career TD passes and 37 career INTs for a 3.35 to 1 TD/INT ratio.
Tom Brady of the New England Patriots is second with 291 career TD passes and 113 career INTs for a 2.58 to 1 TD/INT ratio.
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As of 11/26/2012, Aaron Rodgers has the highest TD/INT ratio with 160 TD/45 INT = 3.56.
Tom Brady is #2 with 324 TD/118 INT = 2.75.
Steve Young is third with 232 TD/107 INT = 2.17.
The quarterback that has the best career touchdown to interception ratio in NFL history is Aaron Rodgers. He has a ratio of 3. 62, and is also the highest rated quarterback of all time.