In Major League Baseball, Barry Bonds has hit the most home runs.
Barry Bonds has the most home runs in Major League Baseball (762).
During the 2011 Major League Baseball (MLB) regular season, the New York Yankees hit the most home runs, with a team total of 222.
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Barry Bonds has the most lifetime home runs in MLB with 762.
Babe Ruth - 714 home runs
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Lou Gehrig hit 23 career grand slam home runs, the most by any player in Major League Baseball history.