Brett Favre holds the record with 464 touchdown passes.
Ask the dogs
Dan Marino holds the record for second most career touchdowns with 418
Former Bears quarterback Sid Luckman holds this record passing for 7 touchdowns on November 14th 1943.
Tom Brady-5 today vs Tennessee..
Tom Brady if your talking about touchdown passes.
Through the 2008 season, that is Dan Marino with 420. Brett Favre holds the record with 463.
Damon Allen holds the record, followed by Anthony Calvillo and Ron Lancaster.