As of the 2008 season, Brett Favre with 442.
Peyton Manning threw for 55 touchdowns in the 2013 season, which is the record for most touchdown passes in a season.
Ask the dogs
In the NFL, Patriots quarterback Tom Brady holds the record for the most passing touchdowns in a single season, with 50 touchdown passes in 2007. In NCAA college football, Brett Elliott of Linfield College (Division III) holds the single season passing touchdown record, with 61 in 2004. The NCAA Division I record is held by Colt Brennan of the University of Hawaii at Manoa, with 58 touchdown passes in 2006. Steve Grogan of the 1976 New England Patriots scored the most rushing touchdowns by a quarterback in NFL history with 12.
Tim Tebow Florida Quarterback 2007 Before Bowl Game 52 touchdowns. 22 Rushing and 30 passing. Over 3,900 yards. I don't think that's right in 2006 Colt Brennan from Hawaii threw for 58 passing TD's. Which is still the record.
Tom Brady if your talking about touchdown passes.
Tom Brady holds the record with 50 touchdown passes