The most sacks in a single game is 12. There are three quarterbacks who have suffered this, Warren Moon, Bert Jones and Donovan McNabb.
Jay Culter of Chicago bears
Derrick Thomas with 7
D.T. Derrick Thomas with 7 sacks for the Kansas City Chiefs against the Seattle Seahawks in 1990.
osi unenora 6 SACKS AGAINST EAGLES IN 2007.
David Carr of the Houston Texans was sacked an NFL record 76 times in the 2002 season.