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I would say 73 points since the Chicago Bears beat the Washington Redskins 73-0 in an NFL Championship game on December 8th, 1940. Not only did Chicago kill the Redskins but they also set a record for most points in a game set by one team so 73 points has to be the biggest score differential in an NFL game.

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14y ago
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15y ago

In the NFL - 73 points - 1940 NFL championship game - Chicago Bears 73, Washington Redskins 0

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12y ago

It was the 1940 NFL championship game, where the Bears beat the Redskins by a score of 73-0.

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Q: What is the NFL game with the largest score differential?
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I don't remember a game with a score of 72-0 but there was a game with the score of 73-0. This was in the 1940 NFL Championship game between the Chicago Bears and the Washington Redskins. The Bears won the game 73-0.