Until the NCAA stripped Memphis of the 2008 season on August 20, 2009 Memphis held the record with a season of 38-1. Unless Memphis' appeal is successful all games in which Memphis fielded an inelligible player, Derrick Rose, will be cancelled resulting in the record being held by the following 4 teams:
 NCAA Champion
 NCAA Runner-up
The most wins in a single NCAA season is 37* - UNLV, Duke (twice), Illinois, and Kansas.
37 - Duke, 1986 (37-3). 37 - UNLV, 1987 (37-2). 37 - Duke, 1999 (37-2). 37 - Illinois, 2005 (37-2). Kansas, 2008 (37-3) & National Champions
Kansas now claims the most wins in a Season, with a National Championship. Previously, each of the teams with 37 win seasons had failed to win the National Championship in their record season.
Really weird when you think about it.
*38 - Memphis, 2008 (38-2) Memphis' record 2008 season with 38 wins has been vacated by the NCAA for numerous rule violations.
*Note: Until it is OFFICIAL, Memphis will still hold this record. The University of Memphis is appealing the decision, so until all that is settled, the 38 wins is still it. IMO, if Duke didn't have to vacate it's wins and Final 4 in 1999 with Corey Maggette ADMITTING to taking money, then why does Memphis? Because they are in a non-BC$ league, that's why.
*Note: It is OFFICIAL. The wins have been vacated and Memphis is currently trying to get them back. **Derrick Rose was not an eligible player and there for should not have played for Memphis in the 2007-08 season. Any game he played in should have and was ruled a loss for Memphis.
**Derrick Rose was not named as the player who didn't take their own SAT but is the only one that fit the criteria given. 1. Freshman During the 2007-08 season 2. Only played one Season at Memphis.
University of Memphis. Memphis went 38-2 in the 2007-2008 season. They lost to Tennessee in the regular season, and Kansas in that epic National Championship game in which Memphis controlled the game, but blew a lead in the last 2 minutes. Not any more. Memphis was ruled in violation of NCAA rules that year, and has been forced to vacate their wins that season. So, effectively, they now went 0-40 that year.
Men's: Kentucky, 2011-12, 38-2
Women's: Baylor, 2011-12, 40-0
UCLA with 88 consecutive victories.
The answer for Division I is Desmond Cambridge(Alabama A&M) with 160 in 2002. I would argue that although Alabama A&M is Division I, Mookie Blaylock (Oklahoma) at #2 in Div. I is the more legitimate record holder at 150 in 1988 because he did it in a major conference. here is the link to the NCAA record book...I had to look around for it. http://web1.ncaa.org/web_files/stats/m_basketball_RB/2009/collegiate.pdf
He played basketball for the University of Michigan from 1940 to 1943. He was the team's leading scorer for two consecutive years and set the school's single season scoring record with 230 points during the 1941-42 season.
The UNC men's basketball team went 8-20 during the 2001-2002 season.
258. Courtesy of the college of Troy.
syracuse vs nova 2012 34,161
Siena Heights University, nuff said...
1982 Wichita State Shockers were 73-14 and established an NCAA record for single-season wins