In 1916, Georgia Tech defeated Cumberland College by the score of 222-0.
wisconson 83 indanna 20
Cumberland lost to Georgia Tech 0 to 222 in 1916.
Wisconsin
FSU destroys Michigan at Michigan. 51-31
Kansas State 59, Oklhaoma 12 - 1969
130-0 vs Michigan on October 22, 1904.
1996 they lost to Ohio State 72-0.
In 1917 Georgia Tech beat Cumberland 222-0
Any loss to Iowa State is arguably the worst loss ever.
The loss of dignity and innocence for the whole program in 2011. Or the 79 Sugar Bowl.
James Madison
There worst lost was against the timberwolves