Assuming you mean defensive holding, the penalty is 10 yards from the basic spot and replay the down.
Note that if the ball is thrown, the "basic spot" is the line of scrimmage, so the 10 yards is enforced from the previous spot, regardless of whether or not the ball is caught. But if the QB tucks the ball and runs, the "basic spot" is the end of the run.
On the other hand, if you meant offensive holding and the hold occurs behind the basic spot, then the 10 yards are enforced from the spot of the foul.
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OPI is a 15yd penalty, against team A. It is penalized 15 yds from the previous spot, and a loss of down.
Well for the first offense there is no penalty. It is just a warning. If their is a second infraction after the warning, that is when the team gets penalized....