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Assuming there is no force at home, chase the runner towards third base and that increases your chance of getting one or perhaps two outs. By throwing home, again assuming no force, the runner could get back to second safely and the throw to home is meaningless.

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Q: On defense if a runner is caught in a run down between 2nd and 3rd and there is a runner on 3rd base should we throw home to not allow the run to score?
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