One of the most game changing moments in a College Football game can be the interception. As the schools enter the 2014-2015 season, the record for the most interceptions in one game belongs to Al Worley.
George Blanda from the Houston threw 42 interceptions in 1962
In 2010 Peyton Manning through 6 interceptions against the Titans
The most interceptions Troy Aikman has thrown in one game is 5 vs New York Giants in the 2000 season.
Kyle orton threw 1,622 interceptions in one game
Most Interceptions ThrownGeorge Blanda (Houston Oilers '62) threw the most interceptions in one season.
Jay Cutler last year against the 49ers who had 6 interceptions; and they still almost won, but Cutler threw a interception on the last drive.
Michael T. Black with 21 playing for the Houston Oilers in 1958 in a game against the Titans.
In 1955, Jim Finks threw 26 interceptions, that was the most by a Steelers quarterback in one season.