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Physically Unable to Perform or PUP prohibits a player from practicing with his team. It is usually a preseason designation.

A player who begins the season on the PUP list must sit out his team's first six games. After that point, the player is allowed to practice with the team through Week 10 of the NFL season, and can be activated any time within that window. If the player is not activated by Week 10, he must stop practicing and is unavailable to be moved to the active roster for the remainder of the season.

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Q: In the NFL What does physically unable to perform mean?
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