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The answer to your question is yes. George Mason (2006) and LSU (1986) both beat #1 seeds as #11 seeds. In 2011, Virginia Commonwealth (VCU) beat #1 Kansas to become the third #11-seed (LSU and George Mason being the first two) to advance to the Final Four.

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Q: Has a 11 seed ever beat a 1 seed in the ncaa mens basketball championship?
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