Well, since USC might mean the University of Southern California or the University of South Carolina ...
Oklahoma State has never played the University of Southern California in football and has played the University of South Carolina twice, losing in the 1979 regular season and winning the 1984 Gator Bowl.
Twice ... in the 1977 and 1983 regular seasons. Oklahoma won in Columbus in 1977 and Ohio State won in Norman in 1983.
Through the 2010 season, no.
Yes
If you're asking whether they have ever played in the Big XII conference championship game, the answer is no. But the conference has only existed since 1996.
Yes, but not since the BCS has been involved
no
If you mean 'OSU' as in Ohio State University, Oklahoma State University, and Oregon State University ...Through the 2008 season, Ohio State University has played two games (1989, 2004) against Oklahoma State University and won both and has played two games against Oregon State University (1974, 1984) and won both. Oklahoma State University and Oregon State University have not met in football.
The BCS Championship Game played January 8, 2009 is the first ever meeting between Oklahoma and Florida in football.
1995 citrus bowl
yes
No, not through the 2010 regular season.
No, they have never met in college football.