No, the Buffalo Bills play in Ralph Wilson Stadium - an traditional outdoor stadium venue- located in Orchard Park about 12 miles south of the city of Buffalo in NY.
one bills drive, orchard park, ny
The Buffalo Bills
New York. Since 2008, the Bills also have played several home games in Toronto, Ontario.
That would be The Buffalo Bills at Ralph Wilson Stadium.
Tickets for the Buffalo Bills home games on the day of the game can be bought from the Ralph Wilson Stadium Ticket Office four (4) hours prior to kickoff.
The Indianapolis Colts play their home games in Indianapolis. The Denver Broncos play their home games in Denver. The Cincinnati Bengals play their home games in Cincinnati. The Buffalo Bills play their home games in Buffalo. (see the pattern here?) Most people would classify Indianapolis and Cincinnati as "midwestern" cities, but that is a question about geography, not football.
All but the Buffalo Bills and the Denver Broncos!
Ralph Wilson Stadium
Technically, only one...the Buffalo Bills. The Meadowlands (home of the Giants and Jets) is in New Jersey.
The Buffalo Bills are based in Buffalo, New York. They are members of the East Division of the American Football Conference (AFC) in the National Football League (NFL). They play their home games in the suburb of Orchard Park, and since the 2008 NFL season through the 2012 NFL season, play one home game per season and three pre-season games in Toronto as part of the 5-year Bills Toronto Series.