Yes and no. The yes comes from simple fact, if the projectile can move down the barrel, it can be fired. I've seen .221 Fireballs fired out of a 7TCU barrel. The no is because you cannot do it well. In effect, if you shoot a slug down a smooth bore shotgun barrel, you will have little in the way of accuracy. Slugs should be shot from a slug barrel, and shot from a smooth bore.
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